Fast Accessibility-Based Prediction of RNA-RNA Interactions
Motivation: Currently, the best RNA–RNA interaction prediction tools are based on approaches that consider both the inter- and intramolecular interactions of hybridizing RNAs. While accurate, these methods are too slow and memory-hungry to be employed in genome-wide RNA target scans. Alternative methods neglecting intramolecular structures are fast enough for genome-wide applications, but are too inaccurate to be of much practical use. Results: A new approach for RNA–RNA interaction was developed, with a prediction accuracy that is similar to that of algorithms that explicitly consider intramolecular structures, but running at least three orders of magnitude faster than RNAup. This is achieved by using a combination of precomputed accessibility profiles with an approximate energy model. This approach is implemented in the new version of RNAplex. The software also provides a variant using multiple sequences alignments as input, resulting in a further increase in specificity. Availability: RNAplex is available at www.bioinf.uni-leipzig.de/Software/RNAplex.
Top- Tafer, Hakim
- Ammann, Fabian
- Eggenhoffer, Florian
- Stadler, Peter F.
- Hofacker, Ivo L.
Category |
Journal Paper |
Divisions |
Bioinformatics and Computational Biology |
Subjects |
Angewandte Informatik Sonstiges |
Journal or Publication Title |
Bioinformatics |
Publisher |
Oxford University Press |
Page Range |
pp. 1924-1940 |
Number |
14 |
Volume |
27 |
Date |
2011 |
Official URL |
http://bioinformatics.oxfordjournals.org/ |
Export |