Bioinformatics of prokaryotic RNAs

Bioinformatics of prokaryotic RNAs

Abstract

The genome of most prokaryotes gives rise to surprisingly complex transcriptomes, comprising not only protein-coding mRNAs, often organized as operons, but also harbors dozens or even hundreds of highly structured small regulatory RNAs and unexpectedly large levels of anti-sense transcripts. Comprehensive surveys of prokaryotic transcriptomes and the need to characterize also their non-coding components is heavily dependent on computational methods and workflows, many of which have been developed or at least adapted specifically for the use with bacterial and archaeal data. This review provides an overview on the state-of-the-art of RNA bioinformatics focusing on applications to prokaryotes.

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Authors
  • Backofen, Rolf
  • Amman, Fabian
  • Costa, Fabrizio
  • Findeiß, Sven
  • Richter, Andreas S.
  • Stadler, Peter F.
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Shortfacts
Category
Journal Paper
Divisions
Bioinformatics and Computational Biology
Journal or Publication Title
RNA Biology
ISSN
1547-6286
Page Range
pp. 470-483
Number
5
Volume
11
Date
April 2014
Official URL
http://dx.doi.org/10.4161/rna.28647
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