Design of transcription regulating riboswitches

Design of transcription regulating riboswitches

Abstract

In this chapter, we review both computational and experimental aspects of de novo RNA sequence design. We give an overview of currently available design software and their limitations, and discuss the necessary setup to experimentally validate proper function in vitro and in vivo. We focus on transcription-regulating riboswitches, a task that has just recently lead to first successful designs of such RNA elements.

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Authors
  • Findeiß, Sven
  • Wachsmuth, Manja
  • Mörl, Mario
  • Stadler, Peter F.
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Editors
  • Abelson, John N.
  • Pyle, Anna M.
  • Colowick, Sidney P
  • Kaplan, Nathan O.
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Shortfacts
Category
Book Section/Chapter
Divisions
Bioinformatics and Computational Biology
Title of Book
Riboswitches as Targets and Tools
Page Range
pp. 1-22
Date
2015
Official URL
http://dx.doi.org/10.1016/bs.mie.2014.10.029
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