Bi-alignments as Models of Incongruent Evolution of RNA Sequence and Secondary Structure

Bi-alignments as Models of Incongruent Evolution of RNA Sequence and Secondary Structure

Abstract

RNA molecules may be subject to independent selection pressures on sequence and structure. This can, in principle, lead to the preservation of structural features without maintaining the exact position on the conserved sequence. Consequently, structurally analogous base pairs are no longer formed by homologous bases, and homologous nucleotides do not preserve their structural context. In other words, the evolution of sequence and structure is incongruent. We model this phenomenon by introducing bi-alignments, defined as a pair of alignments, one modeling sequence homology; the other, structural homology, together with an alignment of the two alignments that models the relative shifts between conserved sequence and conserved structure. Bi-alignments therefore form a special class of four-way alignments. A preliminary survey of the Rfam database suggests that incongruent evolution is not a very rare phenomenon among structured ncRNAs and RNA elements.

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Authors
  • Waldl, Maria
  • Will, Sebastian
  • Wolfinger, Michael T.
  • Hofacker, Ivo L.
  • Stadler, Peter F.
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Shortfacts
Category
Book Section/Chapter
Divisions
Bioinformatics and Computational Biology
Title of Book
Computational Intelligence Methods for Bioinformatics and Biostatistics
Page Range
pp. 159-170
Date
9 December 2020
Official URL
http://dx.doi.org/10.1007/978-3-030-63061-4_15
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