The ability to predict response to medication treatment of depressed patients, either early in the course of therapy or before treatment even begins can avoid trials of ineffective therapy and save patients from prolonged intervals of suffering. Symptom alleviation requires 4–6 weeks after starting current antidepressive medication. Based on the data basis of the patients and their EEG before and on the 7th day of treatment we apply data mining, causal discovery and machine learning approaches to discover interactive patterns between patient’s brain regions to separate the treatment responders from non-responders. In this paper we report the preliminary results of our international project "Learning Synchronization Patterns in Multivariate Neural Signals for Prediction of Response to Antidepressants" ongoing at the University of Vienna, the Czech Academy of Sciences and the National Institute of Mental Health in the Czech Republic.

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