UFBoot2: Improving the Ultrafast Bootstrap Approximation

UFBoot2: Improving the Ultrafast Bootstrap Approximation

Abstract

The standard bootstrap (SBS), despite being computationally intensive, is widely used in maximum likelihood phylogenetic analyses. We recently proposed the ultrafast bootstrap approximation (UFBoot) to reduce computing time while achieving more unbiased branch supports than SBS under mild model violations. UFBoot has been steadily adopted as an efficient alternative to SBS and other bootstrap approaches. Here, we present UFBoot2, which substantially accelerates UFBoot and reduces the risk of overestimating branch supports due to polytomies or severe model violations. Additionally, UFBoot2 provides suitable bootstrap resampling strategies for phylogenomic data. UFBoot2 is 778 times (median) faster than SBS and 8.4 times (median) faster than RAxML rapid bootstrap on tested datasets. UFBoot2 is implemented in the IQ-TREE software package version 1.6 and freely available at http://www.iqtree.org.

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Authors
  • Hoang, Diep Thi
  • Chernomor, Olga
  • von Haeseler, Arndt
  • Minh, Bui Quang
  • Vinh, Le Sy
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Supplemental Material
Shortfacts
Category
Journal Paper
Divisions
Bioinformatics and Computational Biology
Journal or Publication Title
Molecular Biology and Evolution
ISSN
0737-4038
Publisher
Oxford University Press
Place of Publication
Oxford, England, UK
Volume
msx281
Date
25 October 2017
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